Edward Smyth was the nephew of Arthur Smyth, Archbishop of Dublin, 1766-1772. A clergyman of the Church of Ireland, Smyth was ejected from his curacy for supporting the Methodists. Expelled from the Established Church he laboured as an itinerant and was introduced to John Wesley in the Isle of Man in 1777. In 1779 Smyth moved to Bath in Somerset for the sake of his wife's health and was invited to preach at the Methodist Chapel. This caused a dispute between Wesley and the preacher Alexander McNab that resulted in McNab's temporary expulsion from the Connexion.
Smyth returned to Ireland and in 1782 became one of Wesley's clerical assistants in London. In 1786 he was appointed minister of the Bethesda Chapel in Dublin, where he caused a division in the Methodist Society. He later moved to Manchester where he was curate of the churches of St Luke's and St Clement's.
Source: Luke Tyerman, The Life and Times of John Wesley volume 3 (1872), 303-313.